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Value of maintenance therapy with chemotherapy or interferon during remission of acute myeloid leukaemia
Author(s) -
Palva I. P.,
Almqvist A.,
Elonen E.,
Hänninen A.,
Jouppila J.,
Järventie G.,
Koivunen E.,
Kätkä K.,
Lahtinen R.,
Oivanen T.,
Pelliniemi T. T.,
Rajamäki A.,
Remes K.,
Ruutu T.,
Timonen T.,
Wasastjerna C.,
Vilpo J.,
Volin L.,
Vuopio P.
Publication year - 1991
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1991.tb01560.x
Subject(s) - medicine , cytarabine , maintenance therapy , chemotherapy , myeloid leukaemia , surgery , induction chemotherapy , interferon , immunology
108 consecutive patients with de novo acute myeloid leukaemia at ages 15 to 59 years were treated in a prospective controlled multicentre trial. Induction with combination TAD resulted in a complete remission in 85 cases (79%). After a cyclic consolidation programme for 6 months, 73% of the remissions continued. The maintenance therapy was at random either nothing, or alpha interferon, or monthly 5 day courses with thioguanine and cytarabine. The median duration of all remissions was 13 months; that of those in the control and interferon arms 15 months each, and in the chemotherapy arm 18 months. The median survival of all the 108 patients was 16 months; that of those in the control arm 20 months, in the interferon arm 33 months and in the chemotherapy arm 26 months. At 5 yr, 31%, 22% and 31%, respectively, were alive. The survival curves did not differ from each other significantly. Maintenance treatment after an intensive induction and a moderately intensive consolidation was of no benefit in this study. Interferon did not improve the prognosis.