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Occurrence and characteristics of hereditary spherocytosis in Algeria
Author(s) -
Zerhouni F.,
Guetarni D.,
Henni T.,
Colonna P.
Publication year - 1991
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1991.tb00559.x
Subject(s) - hereditary spherocytosis , ankyrin , incidence (geometry) , spherocytosis , abnormality , spectrin , medicine , pediatrics , anemia , demography , outpatient clinic , genetics , biology , mathematics , splenectomy , spleen , cytoskeleton , psychiatry , sociology , gene , cell , geometry
In a survey of more than 12000 persons referred to a hematological outpatient clinic in Algiers, we estimated that the incidence of hereditary spherocytosis (HS) is 1/1000. Another 9 cases were found in nine of the corresponding families. Anemia was present in a total of 44 subjects (81 %). The transmission was dominant in five of eight informative families (63%). No firm conclusion could be reached concerning the amount of spectrin and ankyrin in nine families; however two‐dimensional peptide maps ruled out any alpha11 domain abnormality in these families. We estimate that HS has roughly the same incidence and features among Algerians as in Europeans or people of European descent.