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Non‐lymphoid blast crisis of CML with rearrangement of immunoglobulin and T‐cell receptor delta genes
Author(s) -
Bashey Asad,
Vulliamy Tom,
Cai Bi Su,
Schwarer Anthony P.,
Goldman John M.
Publication year - 1991
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1991.tb00558.x
Subject(s) - terminal deoxynucleotidyl transferase , cd33 , gene rearrangement , cd19 , surface immunoglobulin , immunoglobulin heavy chain , biology , antibody , myeloid , breakpoint cluster region , cancer research , microbiology and biotechnology , immunology , gene , b cell , genetics , tunel assay , immunohistochemistry , stem cell , cd34
We report a patient with chronic myeloid leukaemia (Philadelphia‐positive with M‐BCR rearrangement) in transformation whose blast cells had myelomonocytic morphology, absent terminal deoxynucleotidyl transferase expression and non‐lymphoid cell surface markers (CD10 ‐ , CD19 ‐ , CD33+, CD14+, CD11+). Leukaemia cell DNA showed rearrangement of both immunoglobulin heavy chain and T‐cell receptor δ genes. Such rearrangements may be a feature of a small proportion of patients with non‐lymphoid transformation of CML as they are in a minority of cases of de novo acute non‐lymphoblastic leukaemia.