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Chronic granulocytic leukemia: Reassessment of morphologic and cytogenetic characteristics in Ph 1 ‐positive and Ph 1 ‐negative cases
Author(s) -
Crisan Domnita,
Mattson Joan C.,
AlSaadi A.
Publication year - 1991
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1991.tb00526.x
Subject(s) - basophilia , chronic granulocytic leukemia , peripheral blood , pathology , hemoglobin , gastroenterology , leukemia , medicine
33 cases of chronic granulocytic leukemia (CGL) were reassessed to determine if, by strict morphologic criteria, Philadelphia chromosome (Ph 1 )‐negative CGL exists as a diagnostic entity and if Ph 1 ‐positive CGL could be distinguished from Ph 1 ‐negative CGL. Cases were reassessed using published criteria and, of 11 Ph 1 ‐negative cases, only 4 could be reclassified as myelodysplastic syndromes or undifferentiated chronic myeloproliferative disorder. Of the morphologic parameters evaluated, peripheral blood basophilia and bicytopenia proved to be good discriminators between Ph 1 ‐positive and Ph 1 ‐negative cases. As a group, Ph 1 ‐negative cases were more heterogeneous and tended to have lower hemoglobin, WBC, platelet count and absolute eosinophilia. Chromosomal abnormalities other than Ph 1 were seen only in the Ph 1 ‐positive cases. Based on these findings, we conclude that Ph 1 ‐negative CGL constitutes a heterogeneous group, a subgroup of which is morphologically identical with the Ph 1 ‐positive CGL. The parameters that best discriminate between Ph 1 ‐positive and Ph 1 ‐negative cases are peripheral blood absolute basophilia and bicytopenia.