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Dual rearrangement of immunoglobulin and T‐cell receptor gene in a case of T‐cell hairy‐cell leukemia
Author(s) -
Palumbo Antonio P.,
Corradini Paolo,
Battaglio Silvano,
Omedè Paola,
Coda Renato,
Boccadoro Mario,
Pileri Alessandro
Publication year - 1991
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1991.tb00525.x
Subject(s) - t cell receptor , cd19 , cd8 , hairy cell leukemia , gene rearrangement , cd3 , biology , microbiology and biotechnology , antibody , leukemia , t cell , cd20 , antigen , gene , immunology , immune system , genetics
We report a case of T‐cell hairy‐cell leukemia with a dual rearrangement of Ig‐ and T‐cell receptor genes. The cytochemical, transmission electron microscopy, and surface antigens data (CD3 +, CD8 +, CD11 +, HLA‐DR +, CD19 ‐, CD20 ‐) were consistent with a T‐cell hairy‐cell leukemia. Molecular analysis according to Southern revealed a dual rearrangement of immunoglobulin heavy‐chain (JH) and T‐cell receptor beta (TcRβ) chain genes. Our findings suggest that the coexistence of JH and TcR gene rearrangements, frequently detected in acute leukemia, may also be observed in hematologic malignancies derived from more differentiated cells.