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Relationship between platelet volume and anti‐platelet autoantibodies in idiopathic thrombocytopenic purpura
Author(s) -
Kokawa Terutoshi,
Nomura Shosaku,
Yasunaga Kojiro
Publication year - 1991
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1991.tb00130.x
Subject(s) - mean platelet volume , platelet , autoantibody , medicine , thrombocytopenic purpura , immunology , gastroenterology , antibody
We used flow cytometry to explore the relationship between platelet volume and anti‐platelet autoantibodies in 71 patients with idiopathic thrombocytopenic purpura (ITP). An increase in platelet volume was found more frequently in patients with a platelet count of less than 20000/μl. Platelet volume was larger in patients without anti‐GPIIb/IIIa autoantibodies than in patients with these autoantibodies. Furthermore, the platelet count was significantly lower in patients without anti‐GIIb/IIIa autoantibodies than in the patients with these autoantibodies. There was a positive correlation between a large platelet volume in patients with a platelet count of less than 30000/μl and high platelet‐associated IgM levels. These results suggest that the platelet volume is related to the severity of thrombocytopenia in ITP.