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Studies of in vitro megakaryocytopoiesis in adult immune thrombocytopenic purpura (ITP)
Author(s) -
Bellucci S.,
Han Z. C.,
Caen J. P.
Publication year - 1991
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1991.tb00127.x
Subject(s) - megakaryocytopoiesis , megakaryocyte , thrombocytopenic purpura , progenitor cell , immunology , in vitro , immune system , haematopoiesis , medicine , biology , endocrinology , stem cell , microbiology and biotechnology , biochemistry
In vitro megakaryocytopoiesis was studied in 8 patients with chronic immune thrombocytopenia (ITP). A significant increase of megakaryocyte (MK) colony formation was observed in 5/5 patients studied. Furthermore, the serum of these 8 patients was able to enhance MK colony formation by normal marrow cells. This effect was neither due to a decrease of inhibitors of megakaryocytopoiesis such as betathromboglobulin ((3TG) nor to the IgG fraction of patients' serum. In addition, the level of interleukin 6, which is above all a stimulus for MK maturation, was found within the normal range in 8/8 patients tested. These data suggest that in chronic ITP there is an increase of MK progenitor cell number which may be due to an increased level of MK colony‐stimulating activity.