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In vivo elaboration of CSF in acute inflammation: Proportionality to the intensity of the inflammatory stimulus and requirement of T lymphocytes
Author(s) -
Hamood Mohamad,
Chatelain Christian,
Fondu Pierre,
Symann Michel
Publication year - 1990
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1990.tb00468.x
Subject(s) - inflammation , bone marrow , haematopoiesis , in vivo , granulocyte , immunology , medicine , monocyte , cytokine , endocrinology , biology , stem cell , microbiology and biotechnology
The colony‐stimulating factor(s) (CSF) that stimulates the in vitro growth of bone marrow granulocyte‐monocyte progenitors (CFU‐GM) increases in the serum of mice challenged by an aseptic abscess induced by copper rod insertion. The effect of the inflammation on the increase of serum CSF is dose‐related. The creation of 3 aseptic abscesses indeed results in a higher and longer elevation of serum CSF than 1 abscess. Serum CSF also increases in parallel with the rise in bone marrow CFU‐GM; this is consistent with the CSF playing a role in regulation of haematopoiesis in vivo. From previous studies, it appears that T lymphocytes play a central role in the regulation of haematopoiesis. In order to determine the role of T lymphocytes in the inflammation response, cyclosporin A (CyA), an inhibitor of T lymphocyte function, was given in vivo, 2 days before inflammation induction. CyA abrogates the increase in both serum CSF and CFU‐GM. Furthermore, a lower increase in serum CSF was observed in copper‐implanted nude mice. These results suggest that the CSF production induced by inflammation requires the functional integrity of T lymphocytes.