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Fibroblast colony‐forming cells with high sensitivity to serum mitogen(s) exist in bone marrow of patients with chronic myelocytic leukemia
Author(s) -
Kimura Akiro,
Katoh Osamu,
Hyodo Hideo,
Kusumi Shizuyo,
Kuramoto Atsushi
Publication year - 1990
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1990.tb00397.x
Subject(s) - myelocytic leukemia , bone marrow , fibroblast , leukemia , medicine , myeloproliferative disorders , immunology , endocrinology , biology , cell culture , genetics
Marrow fibroblast colony formation was studied in patients with myeloproliferative disorders, using human serum or platelet‐derived growth factor plus plasma‐derived serum as growth‐stimulating factors. Colony numbers negatively correlated with the patient's age, but were not different from those of controls. However, both maximum and average cell numbers per colony were significantly increased in patients with chronic myelocytic leukemia (CML) as compared to controls. These results suggest that fibroblast colony‐forming cells with high sensitivity to human serum mitogen(s) exist in a CML bone marrow. These may possibly be involved in one of the mechanism concerned with promoting fibrosis in this disease.