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Deletion of 14q in non‐Hodgkin's lymphoma
Author(s) -
Kristoffersson Ulf,
Heim Sverre,
Johnsson Anna,
Mandahl Nils,
Olsson Hakan,
Åkerman Måns,
Mitelman Felix
Publication year - 1990
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1990.tb00390.x
Subject(s) - lymphoma , chronic lymphocytic leukemia , follicular lymphoma , lymphatic system , pathology , breakpoint , medicine , leukemia , non hodgkin's lymphoma , cancer research , biology , chromosomal translocation , immunology , genetics , gene
6 patients with non‐Hodgkin's lymphoma [3 with small cell lymphocytic lymphoma of B‐cell type (SL), and 1 each with follicular centroblastic/centrocytic, centroblastic, and immunoblastic lymphoma] and with the acquired cytogenetic abnormalities del(14) (q22) or del(14) (q24) are described. An evaluation of these 6 cases and 41 other lymphatic neoplasms with 14q deletion known from the literature revealed that 37 had a breakpoint in bands q22 to q24. The deletions occur significantly more often in lymphomas of SL morphology and in the leukemic counterpart, chronic lymphocytic leukemia, than in other types of lymphatic malignancies (p< 0.001).