Premium
Serum erythropoietin and erythropoiesis in patients with myelodysplastic syndromes
Author(s) -
Bowen D. T.,
Jacobs A.,
Cotes P. Mary,
Lewis T. C.
Publication year - 1990
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1990.tb00343.x
Subject(s) - erythropoiesis , erythropoietin , bone marrow , myelodysplastic syndromes , medicine , erythropoietin receptor , anemia , endocrinology , ineffective erythropoiesis , haematopoiesis , biology , microbiology and biotechnology , stem cell
Ineffective erythropoiesis is an early feature of the myelodysplastic syndromes (MDS), usually accompanying an hypercellular marrow. In a previous study, concentrations of serum erythropoietin (EPO) in MDS have been shown to correlate inversely both with haemoglobin concentration and with% bone marrow erythroblasts. We have measured erythroid production using a radioisotopic technique in 20 patients with MDS. Although haemoglobin concentration shows a weak inverse relationship with serum EPO concentration there is considerable variation in EPO concentration at a given haemoglobin level. There is no correlation between serum EPO and total erythroid production, though there is a weak correlation with effective erythropoiesis. The data suggests that control mechanisms of erythropoiesis in patients with MDS are complex.