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Dual rearrangement of immunoglobulin and T‐cell receptor genes in blast crisis of CML
Author(s) -
Uike Naokuni,
Takeichi Naohisa,
Kimura Nobuhiro,
Takahira Hiroyuki,
Kozuru Mitsuo
Publication year - 1989
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1989.tb01471.x
Subject(s) - blast crisis , antibody , gene , cancer research , biology , immunology , genetics , myeloid
Dual rearrangement of immunoglobulin and T‐cell antigen receptor (β, δ) genes was demonstrated in a case of Philadelphia chromosome‐positive chronic myeloid leukemia (CML) in blast crisis. The blast cells, showing L2 morphology and high activity of TdT, expressed pre‐B cell (CD19 + , Ia + ) and myeloid (CD13 + , CD34 + ) surface antigens but lacket T‐cell antigens (CD2‐, CD7). Cytogenetic studies on bone marrow and peripheral blood revealed the Phl chromosome in all metaphases analyzed, majority of which also had the additional chromosome changes, +8, +10, +21. Furthermore, molecular analysis of the breakpoint cluster region (bcr) on chromosome 22 showed a rearrangement, confirming the CML origin of the blast cells.