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Prognostic significance of peripheral blood S + G2/M phase size in adult acute non‐lymphoblastic leukaemia
Author(s) -
Guerci A.,
Pierrez J.,
Kohler F.,
Guerci O.
Publication year - 1989
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1989.tb01245.x
Subject(s) - peripheral blood , medicine , peripheral , lymphoblastic leukemia , oncology , pediatrics , leukemia
Flow cytometric analysis of peripheral blood (PB) S + G2/M phase size was performed in 73 audit patients with untreated acute non‐lymphoblastic leukaemia, to assess whether the results may correlate to response rate and patient prognosis. All patients were treated with the same induction chemotherapy regimen: ARA‐C alone or in combination with an anthracycline antibiotic. Pretreatment PB S + G2/M phase size is significantly correlated to induction response rate (p < 0.02), duration of response (p<0.02) and duration of survival. Patients with low PB S + G2/M phase size experience a longer survival, in patients over and below 50 yr (p < 0.001). Lastly, early deaths tend to be more frequent in the high median age and high PB S + G2/M phase size group. Our study suggests that PB S + G2/M phase size has prognostic significance in obtaining response and duration of survival.