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Behenoyl cytosine arabinoside, aclacinomycin A, 6‐mercaptopurine, and prednisolone combination therapy for acute non‐lymphocytic leukaemia in adults
Author(s) -
Yoshida Minoru,
Suda Keiichi,
Tsuboyama Akihiro,
Sasaki Ryuhei,
Kitagawa Seiichi,
Kano Yasuhiko,
Muto Yoshitomo,
Takaku Fumimaro,
Sakamoto Shinobu,
Miura Yasusada
Publication year - 1989
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1989.tb01243.x
Subject(s) - medicine , prednisolone , vomiting , nausea , gastroenterology , mercaptopurine , aclarubicin , regimen , combination therapy , daunorubicin , cytarabine , surgery , chemotherapy
38 consecutive, previously untreated adult patients with acute non‐lymphocytic leukaemia (ANLL) were treated with BHAC‐AMP (N 4 ‐behenoyl‐1‐β‐D‐arabinofuranosyl‐cytosine, aclacinomycin A, 6‐mercaptopurine, and prednisolone) therapy between March 1980 and February 1985. 25 patients (65.8%) achieved complete remission (CR). Median CR duration and median survival of patients who achieved CR were 14, and 24 months, respectively. The Kaplan‐Meier analysis revealed a probability for remaining in CR of 18.0% at 5 years. Analysis of failure cases revealed that most of them were due to resistant disease. Major toxicities were infection, diarrhoea, liver dysfunction, nausea and vomiting but these were acceptable. The results indicate that BHAC‐AMP therapy is comparable to the regimen with daunorubicin and cytosine arabinoside and a further clinical trial is necessary for previously untreated adult patients with ANNL.