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Accumulation of vincristine and doxorubicin in malignant lymphocytes with different immunophenotypes
Author(s) -
Reizenstein Peter,
Kapoor Rohit,
Gruber Astrid,
Peterson Curt
Publication year - 1989
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1989.tb00334.x
Subject(s) - vincristine , immunoglobulin d , doxorubicin , immunophenotyping , monoclonal antibody , antibody , cancer research , immunology , chemotherapy , microbiology and biotechnology , medicine , biology , b cell , antigen , cyclophosphamide
Cellular accumulation of vincristine (VCR) and doxorubicin (DOX) was studied in 15 patients with low‐grade B‐cell malignancies. Their leukemic lymphocytes were isolated and the effect of verapamil on drug uptake was studied. The immunophenotype was characterized using anti‐IgM, ‐IgD, ‐B 1, monoclonal antibodies. The more that cells bound the IgD or B1 antibodies, the more vincristine and doxorubicin did they accumulate. The fewer the cells that bound IgM antibodies, the more drug did they accumulate.