Premium
Role of autologous lymph node T cells in membrane expression of Mu‐ or Gamma‐ heavy chain isotype by malignant B NHL cells
Author(s) -
Bonnefoix Thierry,
Orfeuvre Hubert,
Jacob MarieChristine,
Piccinni MariePierre,
Sotto JeanJacques
Publication year - 1989
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1989.tb00303.x
Subject(s) - isotype , lymph node , lymph , immunoglobulin class switching , immunology , antibody , immunoglobulin light chain , medicine , b cell , biology , pathology , monoclonal antibody
We investigated the possibility that T cells observed in lymph nodes involved by B‐non‐Hodgkin's lymphomas (B‐NHL) may have a direct role in the expression of Mu‐ or Gamma‐ heavy chain isotype by autologous malignant B cells. T cells were separated from lymph nodes involved by B‐NHL cells expressing either surface IgM (19 cases) or surface IgG (4 cases) and compared to peripheral blood T lymphocytes of healthy subjects (19 cases) for their ability to promote both IgG and IgM secretion in Cowan‐activated normal B lymphocytes. The mean values of IgG/IgM ratios obtained under the influence of T cells associated with malignant B cells expressing either surface IgM or surface IgG were not statistically different to that obtained with the help of control T cells (0.60 and 0.62 versus 0.47, respectively). These results do not account for the hypothesis that autologous lymph node T cells may directly affect the expression of the heavy chain isotype by malignant B‐NHL cells.