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Sialyltransferase activity in plasma cells of multiple myeloma
Author(s) -
Cohen A. M.,
Allalouf D.,
Djaldetti M.,
Weigl K.,
Lehrer N.,
Levinsky H.
Publication year - 1989
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1989.tb00281.x
Subject(s) - bone marrow , multiple myeloma , peripheral blood mononuclear cell , sialyltransferase , medicine , pathology , plasma cell myeloma , bone marrow aspirate , plasma cell , chemistry , biology , microbiology and biotechnology , in vitro , glycoprotein , biochemistry
A marked elevation of sialyltransferase activity (STA) was observed in a solid tumor of plasma cells, which had been removed from a patient with multiple myeloma (MM), as compared to normal lymphatic tissues. STA was also determined in mononuclear bone marrow cells of 10 patients with MM and found to be 12 times higher than that of bone marrow mononuclear cells from 5 patients with non‐malignant disorders (with less than 1% plasma cells in the bone marrow aspirate). A significant correlation was found between STA and the number of plasma cells in the bone marrow aspirate.