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Development of polycythaemia vera in a patient with myelofibrosis
Author(s) -
Dokal I.,
Pagliuca A.,
Deenmamode M.,
Mufti G. J.,
Lewis S. M.
Publication year - 1989
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1989.tb00254.x
Subject(s) - polycythaemia , myelofibrosis , medicine , erythropoiesis , splenectomy , bone marrow , polycythemia vera , ineffective erythropoiesis , spleen , erythropoietin , anemia , pathology , bone marrow examination , gastroenterology
In March 1981, a 53‐year‐old man presented with itching and was diagnosed as having myelofibrosis. There was gradual enlargement of the spleen over the following 5 yr. His spleen had to be removed in February 1986 because of physical discomfort. 3 months post‐splenectomy he became polycythaemic. Bone marrow examination was consistent with severe myelofibrosis. It was possible to demonstrate erythropoietin‐independent BFU‐E from peripheral blood, and ferrokinetic studies showed that erythropoiesis was localised to the liver with little bone marrow activity. Thus, despite severe marrow fibrosis, liver erythropoiesis was now polycythaemic, suggesting the coexistence of myelofibrosis and polycythaemia vera.