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Translocation (1;5)(q23;q33) in adult acute non‐lymphocytic leukemia
Author(s) -
Gyger Martin,
Forest Lorraine,
Lussier Pauline,
D'Angelo Giovanni,
Desy Madeleine
Publication year - 1989
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1989.tb00106.x
Subject(s) - chromosomal translocation , leukemia , bone marrow , abnormality , chromosome , myeloid leukemia , karyotype , acute lymphocytic leukemia , cancer research , biology , cytogenetics , chromosomal abnormality , medicine , genetics , immunology , lymphoblastic leukemia , gene , psychiatry
Chromosome banding studies carried out on bone marrow cells from a 57‐year‐old white caucasian male with an M1 acute non‐lymphocytic leukemia (ANLL) revealed an unbalanced translocation involving chromosomes 1 and 5 [der(5)t(1;5)(q23;q33)] as part of complex abnormalities in 76% of the cells analyzed. This chromosomal abnormality is the first to be reported in an adult patient with acute non‐lymphocytic leukemia. A review of previous reports on translocations involving the juxtaposition of the 1q23 ŕ qter DNA segment to other chromosomes suggests that this new translocation may be specifically involved with abnormal myeloid proliferation.