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Platelet aggregation in platelet rich plasma and whole blood in 18 patients affected by idiopathic myelofibrosis *
Author(s) -
Balduini Carlo L.,
Bertolino Giampiera,
Gamba Gabriella,
Barosi Giovanni,
Sinigaglia Fabiola,
Noris Patrizia,
Bisio Antonella,
Ascari Edoardo
Publication year - 1988
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1988.tb01191.x
Subject(s) - platelet , platelet aggregation , medicine , epinephrine , myelofibrosis , platelet rich plasma , whole blood , endocrinology , mean platelet volume , gastroenterology , bone marrow
Platelet aggregation in whole blood (WB) and in platelet rich plasma (PRP) was studied in 18 consecutive patients affected by idiopathic myelofibrosis (IM). On the basis of WB studies, 22% of patients were classified as normo‐aggregating and 22% as hypo‐aggregating, while 55% had spontaneous platelet aggregation (SPA). SPA was observed also when platelets from patients were stirred in the presence of normal erythrocytes, while it never occurred when normal platelets were stirred in the presence of red cells from patients. PRP studies revealed that 33% and 66% of patients were, respectively, hypo‐ and normo‐aggregating. The most frequent abnormality in PRP was represented by defective or absent aggregation response to epinephrine.