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Alkaline phosphatase‐positive B cell lymphomas
Author(s) -
Abe Masafumi,
Nozawa Yoshihiro,
Wachi Eiko,
Tominaga Kunihiko,
Hojo Hiroshi,
Wakasa Haruki
Publication year - 1988
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1988.tb01185.x
Subject(s) - alkaline phosphatase , lymphoma , mantle cell lymphoma , follicular lymphoma , b cell , non hodgkin's lymphoma , pathology , immunophenotyping , cell , large cell , mantle zone , follicular phase , chemistry , medicine , antibody , immunology , antigen , cancer , enzyme , germinal center , biochemistry , adenocarcinoma
Alkaline phosphatase (ALP) activity of 70 cases of non‐Hodgkin's lymphomas of the B‐cell type was studied. ALP activity was found in malignant lymphoma (ML), follicular, small cleaved cell (1/5 cases); ML, diffuse, small cleaved cell (3/13 cases); and mantle zone lymphoma (intermediate lymphocytic lymphoma) (2/2 cases). The ALP‐positive neoplastic cells simultaneously displayed the characteristic immunophenotype of mantle zone (MZ) B lymphocytes of secondary follicle (SIg D +, BA‐1 +, IL‐2R+ and Leu‐1+). All other B‐cell lymphomas, including ML, follicular, mixed small cleaved and large cell (9 cases); ML, follicular, large cell (4 cases); ML, mixed small and large cell (7 cases); ML, diffuse, large cell (27 cases); and ML, small noncleaved cell (3 cases), were consistently negative for ALP. The present study indicates that ALP‐positive lymphomas including follicular lymphomas and diffuse lymphomas may be neoplastic counterparts of ALP‐positive MZ B lymphocytes.