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‘Auto’‐immune neutropenia after allogeneic bone marrow transplantation unresponsive to conventional immunosuppression but resolving promptly after splenectomy
Author(s) -
Koeppler H.,
Goldman J. M.
Publication year - 1988
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1988.tb00889.x
Subject(s) - medicine , splenectomy , immunosuppression , neutropenia , bone marrow transplantation , immune system , bone marrow , immunology , surgery , spleen , chemotherapy
A 32‐year‐old male presented with isolated neutropenia 6 months after allogeneic bone marrow transplantation for CML from his HLA‐matched brother. The presence of granulocyte‐specific IgM and IgG antibodies in the patient's serum indicated an immune‐mediated basis for the neutropenia. A variety of manoeuvres to suppress antibody production or to reduce peripheral destruction, including high‐dose intravenous immunoglobulins 400 mg/kg (total 24 g) on 5 consecutive days, prednisolone 80 mg for 10 d and plasmapheresis on 3 consecutive d, failed to raise the neutrophil count. Splenectomy, however, resulted in a prompt and sustained rise of neutrophils to normal values.