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Myelodysplastic syndromes: Analysis of morphological features related to the FAB‐classification
Author(s) -
Weide M.,
Sizoo W.,
Krefft J.,
Langenhuijsen M. M. A. C.
Publication year - 1988
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1988.tb00869.x
Subject(s) - medicine , myelodysplastic syndromes , bone marrow , chronic myelomonocytic leukemia , peripheral blood , refractory anemia , pathology
In a retrospective study of 96 patients with a myelodysplastic syndrome, the reproducibility of the French‐American‐British (FAB) classification was determined. Morphological abnormalities in peripheral blood and bone marrow were studied. Slides were reviewed by 3 examiners. All 3 observers agreed on morphological classification in 61% of cases, pairs of 2 in 64, 76 and 76%. The final diagnosis was refractory anaemia (RA) in 7 patients, acquired sideroblastic anaemia (AISA) in 2, chronic myelomonocytic leukaemia (CMML) in 31, refractory anaemia with excess of blasts (RAEB) in 34 and RAEB in transformation (RAEB‐t) in 22. Dyserythropoiesis, dysgranulopoiesis and dysmegakaryopoiesis were found in all FAB subgroups. Dyserythropoiesis was significantly more frequently encountered in RAEB than in RAEB‐t and CMML.