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Partial duplication of chromosome 1q preceding the development of an L3 lymphoblastic leukemia with t(8;14), secondary to treatment for Hodgkin's disease
Author(s) -
Zollino M.,
Genuardi M.,
Santis R.,
Leone G.,
Marra R.,
Mancini R.,
Mango G.,
Neri G.
Publication year - 1988
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1988.tb00823.x
Subject(s) - chromosomal translocation , lymphoblastic leukemia , chromosome , philadelphia chromosome , leukemia , disease , cancer research , cytogenetics , marker chromosome , gene duplication , biology , dup , karyotype , medicine , immunology , pathology , genetics , gene
We report on a case of secondary lymphoblastic leukemia L3 in a patient treated with chemo‐ radiotherapy for a previous Hodgkin's disease. The typical chromosome translocation t(8;14) was found in association with a translocation t(9;19) and a marker chromosome 1, dup(1q). The same marker chromosome had been detected in a few cells of peripheral blood 2 years before the onset of the acute leukemia and may represent a proliferation‐associated change, responsible for the initiation of the process of leukemogenesis.