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Gene probe analysis demonstrates independent clonal evolution of co‐existent chronic myeloid and chronic lymphocytic leukaemia
Author(s) -
Browett P. J.,
Pattinson J.,
Pinkney J.,
Hoffbrand A. V.,
Norton J. D.
Publication year - 1988
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1988.tb00818.x
Subject(s) - breakpoint cluster region , chronic myeloid leukaemia , bone marrow , biology , gene rearrangement , chronic lymphocytic leukemia , gene , breakpoint , population , immunology , myeloid , chromosome , genetics , cancer research , medicine , leukemia , environmental health
We describe a case of Philadelphia‐positive chronic myeloid leukaemia occurring simultaneously with B‐cell chronic lymphocytic leukaemia in a 69‐yr‐old male. Gene probe analysis of DNA from both peripheral blood and bone marrow provided evidence for the independent evolution of 2 clones in this case, with a predominant population showing immunoglobulin heavy chain gene rearrangement and a smaller population showing a rearrangement within the breakpoint cluster region of chromosome 22.