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Cytogenetic follow‐up of 100 patients submitted to bone marrow transplantation for Philadelphia chromosome‐positive chronic myeloid leukemia: Cooperative Study Group on Chromosomes in Transplanted Patients
Author(s) -
Zaccaria Alfonso
Publication year - 1988
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1988.tb00796.x
Subject(s) - cytogenetics , incidence (geometry) , transplantation , myeloid leukemia , bone marrow transplantation , medicine , philadelphia chromosome , chromosome , bone marrow , gastroenterology , leukemia , disease , chromosome abnormality , karyotype , oncology , chromosomal translocation , biology , genetics , physics , gene , optics
100 Ph+ CML patients submitted to BMT were studied cytogenetically before grafting and serially after transplantation. The 12 European institutions participating in the study, including transplant units and laboratories of cytogenetics, collected a total of 520 studies. The Ph chromosome was observed after BMT in 22 patients who did not enter relapse during the observation time (10–1400 days — median 420 d) following initial detection of the chromosome. This abnormality was observed in 1 to 30% of the cells analyzed. In 10 patients, abnormal cells were detected only within the first 90 d after BMT, in 5 patients both before and after 90 d and in 7 patients only after 90 d. 44% of these 22 patients had a moderate‐to‐severe cGVHD. Future studies are needed in order to better evaluate the real incidence of persistent disease and the correlations with the GVHD.