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Immunoelectronmicroscopic investigation of Hodgkin's Disease with monoclonal antibodies against histiocytes
Author(s) -
Hansmann M. L.,
Radzun H. J.,
Nebendahl C.,
Parwaresch M. R.
Publication year - 1988
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1988.tb00792.x
Subject(s) - histiocyte , monoclonal antibody , nodular sclerosis , pathology , monoclonal , antibody , immunohistochemistry , medicine , lymphoma , microbiology and biotechnology , immunology , biology , hodgkin lymphoma
8 cases of Hodgkin's disease (HD nodular sclerosis (n = 3), HD mixed type (n = 2), and nodular paragranuloma (n = 3)) were investigated with monoclonal antibodies against histiocytes (Ki‐M1, Ki‐M3, Ki‐M4, Ki‐M6, and Ki‐M7). Reactivity of H‐ and SR‐cells with the monoclonal antibodies Ki‐M3 and Ki‐M7 could be shown at the ultrastructural level in cases of HD of nodular sclerosis and mixed type. In nodular paragranuloma no positive H‐, SR‐ nor L & H‐cells could be demonstrated. The reaction site of the monoclonal antibodies in H‐ and SR‐cells was comparable to those in histiocytes.