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Aggressive treatment improves survival in adult acute lymphoblastic leukemia
Author(s) -
Smedmyr B.,
Killander A.,
Simonsson B.,
Sundström C.
Publication year - 1988
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1988.tb00230.x
Subject(s) - medicine , vincristine , cyclophosphamide , prednisolone , maintenance therapy , lymphoblastic leukemia , complete remission , regimen , asparaginase , surgery , chemotherapy , leukemia , pediatrics , gastroenterology
20 consecutive adult patients with acute lymphoblastic leukemia were treated with an intense induction regimen including vincristine, doxorubicin, prednisolone, L‐asparaginase and cyclophosphamide. 16 patients (80%) achieved complete remission and were then given CNS prophylaxis and 3 years of maintenance therapy. With minimum follow‐up of 24 months, the median duration of first remission is 37 + months. Out of 10 patients who have completed maintenance therapy, 2 have relapsed after 14 and 22 months, respectively, and 7 are in continuous complete remission 1 + — 55+ months off therapy.