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Pattern of platelet‐associated immunoglobulin (classes and IgG subclasses) in childhood immune thrombocytopenic purpura
Author(s) -
Taaning Ellen,
Petersen Sten
Publication year - 1988
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1988.tb00226.x
Subject(s) - thrombocytopenic purpura , subclass , platelet , immunology , antibody , immune system , medicine , purpura (gastropod) , immunoglobulin g , immune thrombocytopenia , biology , ecology
Platelet‐associated Ig classes and IgG subclasses were studied by a semiquantitative platelet ELISA test in 17 children with immune thrombocytopenic purpura (ITP). An elevation of PAIg was found in 94% of the children. In nearly all cases increased amounts of PAIgG of subclass G1 was seen, and in half of the cases increased amounts of PAIgM were also seen. No statistical difference in the composition of PAIg classes and PAIgG subclasses in acute and in chronic ITP was found. However, a correlation of increased amount of PAIgG3 and very low platelet count (20 × 10 9 /1) was observed.