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Aplastic anemia associated with in vitro inhibition of erythropoiesis by bone marrow‐adherent cells *
Author(s) -
Merchav Shoshana,
Tatarsky Ilana,
Sharon Rivka
Publication year - 1988
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1988.tb00222.x
Subject(s) - aplastic anemia , erythropoiesis , bone marrow , progenitor cell , in vitro , anemia , immunology , cfu gm , medicine , cancer research , stem cell , biology , microbiology and biotechnology , biochemistry
A patient with aplastic anemia that evolved following pure red cell aplasia is described. Cultures of the patient's marrow cells revealed greatly reduced numbers of primitive (BFU‐E) and relatively mature (CFU‐E) erythroid progenitors, but normal numbers of multipotential (CFU‐GEMM) precursors. The BFU‐E/CFU‐GEMM and CFU‐E/BFU‐E ratios in the patient's marrow cell cultures were also reduced. T cell‐ or antibody‐mediated inhibition of in vitro erythropoiesis could not be demonstrated in this patient. However, the patient's marrow‐adherent cells suppressed the growth of autologous and allogeneic BFU‐E and CFU‐E, without influencing the growth of CFU‐GEMM. Medium conditioned by the patient's adherent cells failed to inhibit the growth of normal erythroid precursors. Our findings suggest a role for marrow‐adherent cells in the pathogenesis of aplastic anemia in this patient.