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An increase in basophils in a case of acute myelomonocytic leukaemia associated with marrow eosinophilia and inversion of chromosome 16
Author(s) -
Matsuura Yoshifusa,
Sato Noriharu,
Kimura Fumihiko,
Shimomura Satoshi,
Yamamoto Koichiro,
Enomoto Yasuhiro,
Takatani Osamu
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb01456.x
Subject(s) - basophilia , acute myelomonocytic leukemia , eosinophilia , chromosomal inversion , basophilic , bone marrow , pathology , eosinophil , promyelocyte , medicine , immunology , basophil , biology , chromosome , asthma , karyotype , genetics , immunoglobulin e , gene , antibody
A patient with acute myelomonocytic leukaemia (M4 subtype) with pericentric inversion of chromosome 16, inv(16)(p13q22), and a marked basophilia is described. Results from transmission electron microscopy suggested that the basophils were immature. Clinically, although leukaemic cells had a tendency to infiltrate a number of tissues and organs, such as skin, gingiva, liver and lung, the patient was successfully treated with chemotherapy. The increase in basophils accompanied by marrow eosinophilia may be the result of abnormal differentiation of leukaemic cells that have the capacity to differentiate into both the eosinophilic and basophilic pathways.