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FcR‐mediated clearance in thrombopenic and non‐thrombopenic patients with hemophilia A and possible relation of thrombopenia to HIV seropositivity
Author(s) -
Auch D.,
Budde U.,
Hammerstein U.,
Niese D.,
Schmidt R. E.,
Brackmann H. H.,
Dengler H. J.
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb01453.x
Subject(s) - medicine , antibody , human immunodeficiency virus (hiv) , immunology , immune system , immunopathology , virus , gastroenterology , platelet
As morbidity of thrombopenia in hemophilia A patients is increasing, the pathogenetic influence of the reticuloendothelial system (RES) was measured using autologous anti‐Rh 0 (D)‐coated erythrocytes (EA) in 17 patients with or without thrombopenia. Mean survival of EA in patients was reduced to 53% of healthy controls (53.2 ± 46.1 min vs 100.5 ± 12.2 min; patients vs controls, mean ± S.D.). Survival of EA was not significantly different either in thrombopenic vs non‐thrombopenic nor anti‐HIV (human immunodeficiency virus) positive vs negative patients. Thrombopenia, elevated serum IgG and circulating immune complexes were related to the presence of anti‐HIV antibodies. EA survival was also decreased in the absence of anti‐HIV antibodies. This indicates activation of RES by a mechanism different from retroviral infection by HIV (1).