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Germ‐line configuration of the T‐cell receptor beta‐chain gene in B‐cell chronic lymphoproliferative disorders which co‐express T‐cell antigens
Author(s) -
Morabito Fortunato,
Tassinari Angela,
Callea Vincenzo,
Brugiatelli Maura,
Fierro Maria Teresa,
Saglio Giuseppe,
Neri Alberto,
Foà Robert
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb01448.x
Subject(s) - lymphoproliferative disorders , b cell , immunoglobulin light chain , lymphoma , cd3 , biology , t cell , immunology , antigen , monoclonal antibody , antibody , gene , cell culture , microbiology and biotechnology , genetics , cd8 , immune system
In 7 cases of chronic B‐cell lymphoproliferative disorders – 6 chronic lymphocytic leukaemias and 1 non‐Hodgkin lymphoma in leukaemic phase – which co‐expressed T‐cell markers (CD3, CD2) the clonal origin was investigated at the DNA level. In accordance with the diagnosis, all cases showed a monoclonally rearranged configuration of the immunoglobulin genes. On the contrary, the T‐cell receptor beta chain gene always retained a germ‐line organization. These findings demonstrate that B‐cell chronic lymphoproliferative disorders which co‐express T‐cell‐related markers are truly composed of monoclonal B‐cell elements.