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Monosomy 7 predisposes to diabetes insipidus in leukaemia and myelodysplastic syndrome
Author(s) -
Chapelle Albert,
Lahtinen Reino
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb01447.x
Subject(s) - monosomy , chromosome 7 (human) , diabetes insipidus , medicine , karyotype , bone marrow , aneuploidy , pathology , chromosome , endocrinology , biology , genetics , gene
We studied the chromosomes in the bone marrow of 4 patients who had both diabetes insipidus (DI) and acute non‐lymphocytic leukaemia. Clinical findings suggested that, in each case, myelodysplastic syndrome had preceded the onset of acute leukaemia. Two other such patients described in the literature had had a banded karyotype study of bone marrow cells. All 6 patients had deletions of chromosome 7. 3 had monosomy 7 as the sole cytogenetic abnormality, 2 had monosomy 7 associated with other clonal abnormalities and 1 had del(7)(q22) in association with other abnormalities. These data suggest that monosomy 7 or perhaps monosomy for 7q22‐qter predisposes to DI. The mechanism by which the proposed predisposition is produced remains to be clarified.