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Intravenous gammaglobulin therapy for thromboneutropenic neonates of mothers with systemic lupus erythematosus
Author(s) -
Hanada Takashi,
Saito Kenji,
Nagasawa Toshiro,
Kabashima Teizo,
Nakahara Satoko,
Okuyama Akihiko,
Takita Hitoshi
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb01435.x
Subject(s) - medicine , platelet , regimen , immunology , gamma globulin , immune system , antibody
i.v. IgG therapy was used to treat thromboneutropenia in 2 male neonates of mothers with SLE. The mothers of both neonates were thrombocytopenic but not neutropenic during the last 3 months of their pregnancies. Anti‐platelet and anti‐neutrophil IgG directed against platelets and neutrophils from the neonates were detected in the sera of both mothers. The platelet and neutrophil counts increased significantly with i.v. IgG therapy in both neonates, i.v. IgG therapy is a safe and effective regimen for passive immune thromboneutropenia.