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Expression of CD 25 (Tac antigen) in lymphoid leukemias and non‐Hodgkin lymphomas
Author(s) -
Faure Gilbert C.,
Bene MarieC.,
BolleGhanal MarieH.
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb01419.x
Subject(s) - chronic lymphocytic leukemia , lymphoma , antigen , monoclonal antibody , leukemia , biology , cancer research , immunology , phenotype , b cell , derepression , antibody , gene , gene expression , genetics , psychological repression
A monoclonal antibody to IL2 receptor Tac/CD25 antigen was included in the phenotyping panel of 92 leukemic proliferations. Spontaneous expression of this molecule was observed in one disorder of T‐phenotype only, but in 75% of B‐chronic lymphocytic leukemia (CLL) and on cells from B‐cell leukemic lymphomas. These findings provide further evidence for a non‐T‐cell restriction of IL2 receptor and raise the question of multiple gene derepression in hematologic disorders of B‐lineage.