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Interleukin‐2 can induce proliferation of leukemic B‐cells in prolymphocytic leukemia
Author(s) -
Panayotides Panos,
Porwit Anna,
Lenkei Rodica,
Reizenstein Peter
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb01176.x
Subject(s) - prolymphocytic leukemia , monoclonal antibody , leukemia , microbiology and biotechnology , cancer research , monoclonal , recombinant dna , in vitro , biology , antibody , immunology , chronic lymphocytic leukemia , biochemistry , gene
In a case of prolymphocytic leukemia (PLL), receptors for interleukin‐2 (IL‐2R) were demonstrated by immunofluorescence with a monoclonal antibody against IL‐2R. Highly purified leukemic B‐cells, cultured in vitro with recombinant IL‐2 (r‐IL‐2), responded to IL‐2 with a marked increase of DNA‐synthesis. Both spontaneous and r‐IL‐2‐induced proliferation of leukemic cells were totally abrogated by the anti‐IL‐2R monoclonal antibody.