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Cytogenetic studies in 69 patients with myelodysplastic syndromes (MDS)
Author(s) -
Weh Hans Josef,
Calavrezos Alexander,
Seeger Doris,
Kuse Rolf,
Hossfeld Dieter Kurt
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb01157.x
Subject(s) - myelodysplastic syndromes , incidence (geometry) , cytogenetics , medicine , chromosome , karyotype , oncology , pathology , biology , genetics , bone marrow , gene , physics , optics
Cytogenetic studies were performed in 69 patients with myelodysplastic syndromes classified according to the FAB proposals. Overall incidence of chromosomal anomalies was 48% with 5q‐, +8, 12p‐,‐7/7q‐ being the aberrations most often found. The 12p‐ chomosome showed a close correlation with a prior exposure to mutagenic agents and CMML. Although there were no group‐specific cytogenetic anomalies, FAB classification strongly influenced their incidence. They were lower (36%) in RA/RA‐S than in RAEB/RAEB‐T/CMML (53%). Chromosomal anomalies were significantly more often found in patients with a prior exposure to carcinogenic agents (80%) than in unexposed patients (33%). The presence of chromosomal anomalies did not predict a higher risk of leukemic transformation.