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B‐cell chronic lymphocytic leukaemia with aberrant expression of CD8 antigen
Author(s) -
Porwit A.,
Borgonovo L.,
ösby E.,
Lenkei R.,
Smith C. I. E.,
Hammarström L.
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb00775.x
Subject(s) - cytotoxic t cell , antigen , cd8 , biology , antibody , monoclonal antibody , microbiology and biotechnology , gene , immunology , genetics , in vitro
The monoclonal antibodies against CD8 (T suppressor/cytotoxic) antigen (Leu2/OKT8) were found to bind to leukaemic lymphocytes from a patient with chronic lymphocytic leukaemia. The cells also had an unusual type of rod‐like cytoplasmic immunoglobulin of IgM/γ type as seen by light, fluorescence and electron microscopy, and displayed several antigens characteristic for B lymphocytes. Gene rearrangement analysis showed rearrangement of μ heavy chain gene. In spite of an expression of CD8 antigen, T‐cell receptor genes were not rearranged.