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Correlation between bone marrow karyotype and the occurrence of erythroblast micronuclei and nuclear budding in patients with myelodysplastic syndromes
Author(s) -
Teerenhovi L.,
Lintula R.,
Ruutu T.,
Knuutila S.
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb00764.x
Subject(s) - micronucleus test , myelodysplastic syndromes , erythroblast , bone marrow , karyotype , micronucleus , biology , monosomy , pathology , chromosome aberration , bone marrow failure , cytogenetics , chromosome , immunology , medicine , genetics , haematopoiesis , stem cell , toxicity , gene
147 patients with myelodysplastic syndromes were investigated for the presence of micronuclei and nuclear budding in bone marrow erythroblasts. The patients were divided into subgroups on the basis of bone marrow karyotype. 31 healthy bone marrow donors constituted a control group. Patients with monosomy 7 or 7q‐ and patients with major karyotypic abnormalities (MAKA) had significantly more erythroblasts with micronuclei and nuclear budding than the control group. Patients with a 5q‐ chromosome as the sole karyotypic aberration had more micronuclei than the controls. For other patients with MDS the differences were statistically nonsignificant.