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Polyclonal B‐cell activation after intravenous immunoglobulin therapy in idiopathic thrombocytopenic purpura — an anti‐idiotype response?
Author(s) -
Wangel A. G.,
Lorenzetti M.,
Pettersson T.
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb00759.x
Subject(s) - thrombocytopenic purpura , polyclonal antibodies , idiotype , antibody , medicine , immunology , intravenous immunoglobulin therapy , monoclonal , platelet , monoclonal antibody
Polyclonal B cell activation occurred in 3 patients following treatment with intravenous immunoglobulin (i.v. Ig) for idiopathic thrombocytopenic purpura (ITP). The possibility that this may represent an anti‐idiotype response and the hypothesis that prolonged remission of ITP may be induced by this mechanism are discussed.