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The treatment of adult idiopathic thrombocytopenic purpura
Author(s) -
Simon Marc,
Jouet JeanPierre,
Fenaux Pierre,
Pollet JeanPaul,
Walter MariePierre,
Bauters Francis
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb00756.x
Subject(s) - medicine , thrombocytopenic purpura , contraindication , prednisone , refractory (planetary science) , bolus (digestion) , vinca , vinca alkaloid , platelet , gastroenterology , surgery , intravenous bolus , anesthesia , chemotherapy , vincristine , cyclophosphamide , pharmacology , astrobiology , physics , alternative medicine , pathology
16 adult idiopathic thrombocytopenic purpura (ITP) patients, with mean age 51 years, were treated by 5 weekly slow intravenous infusions of vinblastine (0.1 mg/kg). When a complete or partial response (CR or PR) was obtained, slow infusions were repeated at 2‐weekly then monthly intervals, as maintenance therapy. In 4 cases with ITP of recent onset, but presenting contraindication or failure to prednisone and high dose intravenous immunoglobulins, CR was obtained in all patients after 4 to 15 days (mean 9.5). Only one of these patients relapsed. In 12 cases of refractory chronic ITP (of whom 10 had been splenectomized), there were 2 CR, 6 PR and 4 failures. The 8 responding patients had a mean interval to response of 20 days. The 6 PR were short and did not exceed 15 days. Our results do not support a superiority of this treatment compared to other modes of administration of vinca alkaloids in ITP (intravenous bolus, vinca loaded platelets).