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Platelet glucose metabolism in Type I diabetic subjects
Author(s) -
Leoncini G.,
Maresca M.,
Balestrero F.,
Polvani C.,
Arrnani U.,
Piana A.
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb00748.x
Subject(s) - medicine , hexokinase , endocrinology , glycolysis , platelet , hexose , chemistry , arachidonic acid , carbohydrate metabolism , metabolism , glycogen , pentose phosphate pathway , biochemistry , enzyme
In a group of 35 type I diabetics, platelet glycolytic and glycogenolytic flux have been measured. In type I diabetic platelets glucose uptake was significantly reduced. The quite normal lactate production was obtained by a faster utilization of stored glycogen in these patients. Specific activity of glycolytic enzymes was normal, in particular the levels and kinetic properties of soluble and membrane bound hexokinase. The rate of glucose flux through the hexose monophosphate shunt, measured either in resting or in arachidonic acid‐stimulated platelets, was normal in diabetics. Kinetics of glucose transport across plasma membrane have also been determined. Km was significantly increased in diabetic patients. No changes was shown in Vmax. Modifications present in membrane organization of patients could involve glucose transport protein.