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S protein/vitronectin in chronic liver diseases: correlations with serum cholinesterase, coagulation factor X and complement component C3
Author(s) -
KemkesMatthes B.,
Preissner K. T.,
Langenscheidt F.,
Matthes K. J.,
MüllerBerghaus G.
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb00747.x
Subject(s) - vitronectin , coagulation , complement system , cirrhosis , complement factor i , medicine , cholinesterase , complement (music) , endocrinology , immunology , chemistry , biochemistry , antibody , receptor , integrin , complementation , gene , phenotype
S protein/vitronectin plays an important role as a regulatory component in the terminal steps of the complement‐ and coagulation cascades. In patients suffering from chronic liver diseases, plasma S protein concentration was measured and compared with changes in serum cholinesterase activity, coagulation factor X activity and complement component C3 concentration. Significant decreases of all these proteins were seen in liver cirrhosis. Changes in S protein concentration correlated closely with those of cholinesterase, factor X and complement C3. The data give support for the liver as the main organ of plasma S protein/vitronectin synthesis.