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Glucocorticoid receptor in multiple myeloma
Author(s) -
Murakami Tohru,
Togawa Atsushi,
Satch Hiroshi,
Katoh Minako,
Imamura Yukio,
Ohsawa Nakaaki,
Takaku Fumimaro
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb00164.x
Subject(s) - glucocorticoid receptor , glucocorticoid , dexamethasone , multiple myeloma , receptor , endocrinology , medicine , cell culture , chemistry , biology , genetics
Glucocorticoid receptor levels of myeloma cells were quantitated in 7 patients with multiple myeloma. In 4 patients, glucocorticoid receptor levels were less than 10 fmol/10 6 cells. In 3 patients, receptor levels were from 17.6 to 21.4 fmol/10 6 cells. We further examined the correlation between glucocorticoid receptor levels and effect of dexamethasone on 14 C‐thymidine incorporation and cell viability using 2 myeloma cell lines, OPM‐1 and OPM‐2, established from a patient with multiple myeloma. Glucocorticoid receptor levels of OPM‐1 and OPM‐2 were 8.5 fmol/10 6 cells and 63.2 fmol/10 6 cells, respectively. The sensitivity of OPM‐1 to dexamethasone in these studies was lower than that of OPM‐2. These results suggest the possibility that the low level of glucocorticoid receptor in myeloma cells may be important for predicting a poor response to glucocorticoid therapy.