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Alpha‐thalassaemia in Nigeria: Its interaction with sickle‐cell disease
Author(s) -
Falusi A. G.,
Esan G. J. F.,
Ayyub H.,
Higgs D. R.
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb00013.x
Subject(s) - disease , hemoglobinopathy , sickle cell anemia , genotype , cell , population , medicine , thalassemia , globin , gene , immunology , genetics , biology , hemoglobin , environmental health
We have determined the molecular basis and frequency of α‐thalassaemia in Nigeria. The a‐thalassaemia determinant in this population is caused by only one type of single α globin gene deletion (‐α 3.7 ). Comparison of the haematological features of those patients who have sickle‐cell disease with (‐α/αα, ‐α/‐α) or without (αα/αα) α‐thalassaemia showed similar trends to those reported in Jamaican and U.S. patients with these interactions. However, in contrast to studies in some other African populations we have shown that the frequency of α‐thalassaemia in Nigeria is the same (0.24) in patients with or without homozygous sickle‐cell disease (AA, AS and AC genotypes).