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Tseudo‐lymphoid‘ leukaemia with unusual features: Ultrastructural, immunological, cytogenetic and molecular studies
Author(s) -
Matutes Estela,
Foroni Letizia,
Amin S.,
Oliveira Maria P.,
BritoBabapulle Vasantha,
Luzzatto L.,
Catovsky D.
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb00002.x
Subject(s) - myeloid , biology , monosomy , pathology , antigen , microbiology and biotechnology , bone marrow , karyotype , immunology , chromosome , gene , genetics , medicine
An unusual case of ‘pseudo‐lymphoid’ leukaemia is described. The leukaemic cells resembled small, mature lymphocytes but lacked B‐ and T‐cell membrane markers as well as immunoglobulin (Ig) and T‐cell receptor gene rearrangements. They showed, instead, features of early myeloid cells since they expressed 2 myeloid antigens, CDW13 and My9, and displayed peroxidase activity demonstrable by electron microscopy (EM) on unfixed cells. Cytogenetic studies showed monosomy 5, t(4;17) (p12;p11), t(2;3)(p23;q14) and an abnormal chromosome 12. Abnormalities of chromosomes 4 and 5 have been previously associated with ‘pseudo‐lymphoid’ leukaemias. This case illustrates the value of sensitive methods for the characterization of blast cells and for the precise diagnosis of leukaemias with apparent ‘lymphoid’ morphology.