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The use of hydroxocobalamin in the Schilling test
Author(s) -
Wallis J.,
Clark D. M.,
Bain B. J.
Publication year - 1986
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1986.tb02323.x
Subject(s) - hydroxocobalamin , cyanocobalamin , medicine , flushing , vitamin b12 , gastroenterology , endocrinology
Hydroxocobalamin and cyanocobalamin have been compared as the ‘flushing dose’ in the Schilling test. In healthy, haematologically normal subjects excretion of the test dose was greater following a hydroxocobalamin flushing dose than following a cyanocobalamin flushing dose, and to a lesser extent this was also true in patients requiring investigation. There were occasional discrepant results, but in general it appears that, although reference values differ, hydroxocobalamin is a suitable replacement for cyanocobalamin in the Schilling test.