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Lymphocyte subpopulations in megaloblastic anaemia due to vitamin B‐12 deficiency
Author(s) -
Gogos C. A.,
KapataisZournbos K. N.,
Zoumbos N. C.
Publication year - 1986
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1986.tb02319.x
Subject(s) - pernicious anaemia , immune system , immunology , autoantibody , lymphocyte , medicine , antibody
Lymphocyte subpopulations were measured in the blood of 17 patients with megaloblastic anaemia due to vitamin B‐12 deficiency. 14 patients had pernicious anaemia and 3 others were gastrectomized. By using monoclonal antibodies recognizing T cell surface markers and immunofluorescence microscopy, we found a significant decrease in the number of circulating suppressor T cells and an increase in the ratio of helper to suppressor T lymphocytes in pernicious anaemia patients. This finding may be related to other immune abnormalities found in pernicious anaemia, e.g. the presence of multiple autoantibodies.