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Impaired chemiluminescence response by neutrophils in patients with multiple myeloma
Author(s) -
Dammacco F.,
Miglietta A.,
Perfetto S. C.
Publication year - 1986
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1986.tb02314.x
Subject(s) - medicine , multiple myeloma , monoclonal gammopathy of undetermined significance , chemiluminescence , neutrophile , gastroenterology , absolute neutrophil count , immunology , monoclonal , inflammation , monoclonal antibody , toxicity , antibody , chemistry , neutropenia , organic chemistry
Neutrophil chemiluminescence (CL) as a measure of oxygen‐dependent killing activity was evaluated in 3 groups of patients: (a) 63 patients with multiple myeloma (MM); (b) 31 subjects with monoclonal gammopathy of undetermined significance (MGUS); (c) 32 healthy controls. Neutrophil CL response was shown to be significant reduced both in patients with MM (p < 0.001) and in subjects with MGUS (p < 0.001). A significant difference was also observed between the results obtained in MM and those of MGUS (p < 0.001). Treated MM patients showed a more severe impairment of neutrophil chemiluminesccence response than that observed in untreated patients (p < 0.001). It is suggested that the impairment of neutrophil CL response, possibly related to decreased killing activity, may play a role, along with other known causes, in the increased susceptibility to infection observed in MM patients.